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The project will deliver a novel aid for use in triage to support early and accurate diagnosis of Parkinsons disease (PD). The PD Pen could radically change the way patients are screened and referred to specialists by leveraging at GP level of care to create greater efficiency in utilization of specialty centers; make the process more convenient for patients and speed up access to specialists when needed. The Pen can also be used in disease monitoring - crucial along with timely diagnosis - to keep patients well and establish cost savings through optimising treatment. The accuracy of prototype clinical validation was 80%.

There are approximately 123,000 cases of sepsis per year in England and around 36,800 associated deaths - of which 70% of cases come from the community. Medtechtomarket Consulting Ltd have demonstrated a proof of concept (patent filed) for a novel, highly sensitive, simple and low cost test for the early diagnosis and subsequent therapy monitoring of Sepsis. This project proposal focuses on performance feasibility studies, and establishing a clinical advisory panel. The vision is that GPs will be able to test for sepsis much sooner and more often, reducing uncertainty and allowing treatment to start in the critical early stages.

Biomarkers have the potential to revolutionize the diagnosis and management of psychiatric disorders which affects 1 in 5 of us during our lifetime. The present symptom based diagnoses are unreliable with more than 50% of cases misdiagnosed at first presentation leading to suboptimal, inappropriate or even dangerous treatments. We have developed SaccScan - a Point-of-Care tool which has been demonstrated to detect schizophrenia and related illnesses with better than 95% accuracy. Early economic modelling showed that early detection of schizophrenia using SaccScan could produce savings of £33,474 per patient in the case of suspected schizophrenia alone.